Ingredients, explained.
What the ingredients on your labels actually do, how strong the evidence is, and the free, full-text studies behind each claim. 45 ingredients, 84 studies.
2% salicylic acid
Also listed as Beta hydroxy acid, BHA
- What it's claimed to do
- Unclogs pores, smooths texture, and reduces breakouts.
- What the evidence says
- Salicylic acid is oil-soluble and well established for comedonal acne and exfoliation. Daily use can irritate dry or sensitive skin.
- In Paula's Choice 2% BHA Liquid Exfoliant →
- Salicylic acid as a peeling agent: a comprehensive review ↗
Clinical, cosmetic and investigational dermatology · 2015 · DOI 10.2147/CCID.S84765
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This review describes salicylic acid's properties as a peeling agent, noting its comedolytic and desmolytic (disrupting cellular junctions) actions are useful for treating conditions like acne.
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne ↗
The Cochrane database of systematic reviews · 2020 · DOI 10.1002/14651858.CD011368.pub2
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Salicylic acid helps acne, but trial evidence comparing it with other treatments was rated low certainty.
415nm blue light
- What it's claimed to do
- Kills acne bacteria.
- What the evidence says
- Blue light does reduce C. acnes counts and inflammatory lesions in trials, but it underperforms standard acne treatments and results fade when you stop.
- In Lumen Form LED Red Light Therapy Mask →
- Effect of Blue Light on Acne Vulgaris: A Systematic Review ↗
Sensors (Basel, Switzerland) · 2021 · DOI 10.3390/s21206943
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A systematic review of randomized trials found that blue light phototherapy showed significant improvements in the overall picture of acne, but concluded more detailed trials are needed.
- Phototherapy as a Treatment for Dermatological Diseases, Cancer, Aesthetic Dermatologic Conditions and Allergenic Rhinitis in Adult and Paediatric Medicine ↗
Life (Basel, Switzerland) · 2023 · DOI 10.3390/life13010196
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Reviews light therapies in dermatology, including blue light for mild-to-moderate acne.
633nm red light
- What it's claimed to do
- Boosts collagen and smooths wrinkles.
- What the evidence says
- Photobiomodulation has real clinical literature showing improved collagen density and skin texture. Most trials use clinic-grade devices with far higher irradiance than consumer masks.
- In Lumen Form LED Red Light Therapy Mask →
- A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase ↗
Photomedicine and laser surgery · 2014 · DOI 10.1089/pho.2013.3616
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Significant improvement in collagen density and roughness versus untreated controls.
- Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring ↗
Seminars in cutaneous medicine and surgery · 2013 · PMC4126803
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This review suggests low-level light therapy works by photons being absorbed by mitochondrial chromophores, activating signaling pathways that can stimulate tissue repair, reduce UV damage, and manage inflammatory skin diseases.
96% snail secretion filtrate
- What it's claimed to do
- Hydrates, repairs the barrier, and fades marks.
- What the evidence says
- Snail filtrate contains humectant glycosaminoglycans and bioactive proteins. Hydration is credible; scar and pigmentation evidence is much less certain.
- In COSRX Advanced Snail 96 Mucin Power Essence →
- Hidden benefits of snail mucus: A natural skincare marvel ↗
Biomolecules & biomedicine · 2024 · DOI 10.17305/bb.2024.11067
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Early studies support hydrating and regenerative properties, but robust human trials remain sparse.
- Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging ↗
The Journal of clinical and aesthetic dermatology · 2020 · PMC7159309
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A small study of a snail-based regimen reported smoother fine lines; it combined several ingredients, so snail's own effect can't be isolated.
Apigenin
Also listed as Chamomile extract
- What it's claimed to do
- Binds sleep receptors like a natural sedative.
- What the evidence says
- Receptor binding is real in the lab. Human sleep trials using chamomile are few, small and inconsistent.
- In Hush Labs Magnesium Glycinate Sleep Capsules →
- Chamomile: A herbal medicine of the past with bright future ↗
Molecular medicine reports · 2010 · DOI 10.3892/mmr.2010.377
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A review of chamomile notes its traditional use for various ailments, including insomnia, and that its medicinal properties are attributed to terpenoids and flavonoids in its dried flowers.
- Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study ↗
BMC complementary and alternative medicine · 2011 · DOI 10.1186/1472-6882-11-78
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In a small pilot trial, chamomile extract did not significantly improve sleep compared with placebo.
Ashwagandha root extract
Also listed as Withania somnifera
- What it's claimed to do
- Lowers cortisol and de-puffs your face.
- What the evidence says
- Several randomised trials show reduced stress scores and modest cortisol drops over 8 weeks. Many are small and industry-funded. Rare but documented liver-injury case reports exist.
- In Steady State KSM-66 Ashwagandha Cortisol Complex →
- A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults ↗
Indian journal of psychological medicine · 2012 · DOI 10.4103/0253-7176.106022
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Significant reduction in serum cortisol and stress scales versus placebo at 60 days.
- Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network ↗
Liver international : official journal of the International Association for the Study of the Liver · 2020 · DOI 10.1111/liv.14393
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Documents rare hepatotoxicity, typically reversible after stopping.
Bakuchiol
- What it's claimed to do
- A natural retinol alternative with zero irritation.
- What the evidence says
- One small randomised trial found it comparable to retinol over 12 weeks, but sample sizes are tiny and independent replication is limited.
- In Northlight Lab Overnight Retinal 0.1% Serum →
- Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing ↗
The British journal of dermatology · 2019 · DOI 10.1111/bjd.16918
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Bakuchiol and retinol both reduced wrinkle area; bakuchiol caused less scaling and stinging.
- Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin ↗
Clinical, cosmetic and investigational dermatology · 2020 · DOI 10.2147/CCID.S235880
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In an open-label clinical study, a serum combining bakuchiol and vanilla tahitensis extract was found to reduce facial ptosis (sagging), improve skin firmness, and increase radiance.
Bis-aminopropyl diglycol dimaleate
- What it's claimed to do
- Repairs broken disulfide bonds inside damaged hair.
- What the evidence says
- The patented chemistry is plausible, and reduced breakage is consistent with conditioning treatments, but independent human studies isolating this molecule are scarce.
- In Olaplex No. 3 Hair Perfector →
- Hair cosmetics: an overview ↗
International journal of trichology · 2015 · DOI 10.4103/0974-7753.153450
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This article reviews the formulations and mode of action of hair cosmetics like shampoos and conditioners to help dermatologists treat hair and scalp conditions.
Brief topical cooling
- What it's claimed to do
- Shrinks pores, reduces puffiness, and lifts the face.
- What the evidence says
- Cooling temporarily constricts blood vessels and may reduce superficial swelling. It cannot permanently shrink pores or lift tissue, and direct prolonged ice contact can injure skin.
- In Morning self-care Facial Ice Rolling →
- Local thermal control of the human cutaneous circulation ↗
Journal of applied physiology (Bethesda, Md. : 1985) · 2010 · DOI 10.1152/japplphysiol.00407.2010
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Cooling the skin narrows its small blood vessels; the response is temporary and reverses as skin rewarms.
- Sustained cutaneous vasoconstriction during and following cyrotherapy treatment: Role of oxidative stress and Rho kinase ↗
Microvascular research · 2016 · DOI 10.1016/j.mvr.2016.04.005
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Skin blood vessels stayed narrowed during and after cold application in this laboratory study.
Broad-spectrum organic UV filters
- What it's claimed to do
- Protects from UVA and UVB without a white cast.
- What the evidence says
- Properly tested sunscreen filters reduce UV damage. The clear silicone gel improves wearability, but protection still depends on applying enough and reapplying.
- In Supergoop! Unseen Sunscreen SPF 40 →
- Visible light. Part II: Photoprotection against visible and ultraviolet light ↗
Journal of the American Academy of Dermatology · 2021 · DOI 10.1016/j.jaad.2020.11.074
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Conventional sunscreens with UV filters do not protect against visible light, only tinted sunscreens do, and future development should focus on this protection gap while improving the cosmetic feel of products.
Bronzing pigments + cocoa extract
- What it's claimed to do
- Adds sun-kissed color while defending against pollution.
- What the evidence says
- Mineral pigments create immediate color. Cocoa antioxidants are plausible in laboratory models, but pollution-defense claims for the finished product are not strongly demonstrated clinically.
- In Drunk Elephant D-Bronzi Anti-Pollution Sunshine Drops →
- Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials ↗
Frontiers in medicine · 2026 · DOI 10.3389/fmed.2026.1618306
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This meta-analysis of 19 randomized controlled trials found that peptides, particularly oral formulations, significantly improved skin hydration and brightness, with a modest effect on wrinkle reduction.
- Chocolate flavanols and skin photoprotection: a parallel, double-blind, randomized clinical trial ↗
Nutrition journal · 2014 · DOI 10.1186/1475-2891-13-66
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Eating high-flavanol chocolate did not significantly change UV sensitivity; the trial studied diet, not cocoa applied to skin.
Carrageenan
- What it's claimed to do
- Soothes the gut.
- What the evidence says
- Carrageenan extracted from this seaweed is a common food thickener; some animal data raises gut-inflammation questions, and whole-seaweed effects are not the same as isolated additive effects.
- In Atlantic Bloom Wildcrafted Sea Moss Gel →
- The Role of Carrageenan and Carboxymethylcellulose in the Development of Intestinal Inflammation ↗
Frontiers in pediatrics · 2017 · DOI 10.3389/fped.2017.00096
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Animal models suggest inflammatory potential; human relevance is disputed.
- Carrageenan in the Diet: Friend or Foe for Inflammatory Bowel Disease? ↗
Nutrients · 2024 · DOI 10.3390/nu16111780
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Animal studies suggest degraded carrageenan can trigger intestinal inflammation and increase gut permeability, but its effects on humans with IBD are not yet sufficiently researched.
Castor oil
- What it's claimed to do
- Thickens and lengthens hair.
- What the evidence says
- No human trials support growth. It coats strands so hair looks glossier and heavier, and heavy use is linked to matting in some case reports.
- In Wildroot Co. Rosemary Mint Scalp Growth Oil →
- Hair cosmetics: an overview ↗
International journal of trichology · 2015 · DOI 10.4103/0974-7753.153450
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This overview article reviews the formulations and mode of action of various hair cosmetics, including shampoos, conditioners, and hair dyes.
- Use of Castor Oil in Dermatology: A Narrative Review ↗
Cureus · 2026 · DOI 10.7759/cureus.103289
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Reviews castor oil's skin and hair uses and the limited clinical evidence behind them.
Cold-water immersion
- What it's claimed to do
- Speeds recovery, boosts mood, and builds resilience.
- What the evidence says
- Cold-water immersion can modestly reduce perceived muscle soreness after hard exercise. The mood and immune claims are less certain, and regular post-strength plunges may blunt some muscle-building adaptations.
- In Recovery ritual Cold Plunge Routine →
- Cold-water immersion (cryotherapy) for preventing and treating muscle soreness after exercise ↗
The Cochrane database of systematic reviews · 2012 · DOI 10.1002/14651858.CD008262.pub2
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Cold immersion reduced soreness compared with passive recovery, although study quality and protocols varied.
- Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training ↗
The Journal of physiology · 2015 · DOI 10.1113/JP270570
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Regular cold immersion after resistance exercise may weaken molecular signals involved in muscle adaptation.
Cupuaçu butter
- What it's claimed to do
- Deeply moisturizes body skin.
- What the evidence says
- Rich plant lipids reduce water loss and soften dry surface skin, though this butter is not uniquely superior to other emollients.
- In Sol de Janeiro Brazilian Bum Bum Cream →
- Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils ↗
International journal of molecular sciences · 2017 · DOI 10.3390/ijms19010070
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A review of various plant oils finds they can have therapeutic benefits for skin, including anti-inflammatory effects, promotion of wound healing, and repair of the skin barrier.
- Theobroma cacao and Theobroma grandiflorum: Botany, Composition and Pharmacological Activities of Pods and Seeds ↗
Foods (Basel, Switzerland) · 2022 · DOI 10.3390/foods11243966
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Cupuaçu beans, used in cosmetics, are rich in fats, bioactive compounds like polyphenols, and are considered a promising healthy resource.
Forced nasal breathing
- What it's claimed to do
- Stops snoring and improves sleep by keeping the mouth closed.
- What the evidence says
- Evidence is limited to small studies in selected people. Mouth breathing can be a sign of nasal obstruction or sleep apnea, and taping may add risk rather than treat the cause.
- In Sleep trend Mouth Taping at Night →
- The Impact of Mouth-Taping in Mouth-Breathers with Mild Obstructive Sleep Apnea: A Preliminary Study ↗
Healthcare (Basel, Switzerland) · 2022 · DOI 10.3390/healthcare10091755
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A small preliminary study found improvements in selected adults with mild sleep apnea; it does not establish broad safety or effectiveness.
- Breaking social media fads and uncovering the safety and efficacy of mouth taping in patients with mouth breathing, sleep disordered breathing, or obstructive sleep apnea: A systematic review ↗
PloS one · 2025 · DOI 10.1371/journal.pone.0323643
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A systematic review found little high-quality evidence that mouth taping improves sleep, and noted possible risks.
Guaraná extract + caffeine
- What it's claimed to do
- Stimulates microcirculation and visibly firms skin.
- What the evidence says
- Caffeine can temporarily affect local circulation and water balance, but evidence for durable firming or cellulite reduction from a cosmetic cream is weak.
- In Sol de Janeiro Brazilian Bum Bum Cream →
- Caffeine's mechanisms of action and its cosmetic use ↗
Skin pharmacology and physiology · 2013 · DOI 10.1159/000343174
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Topical caffeine is biologically active, but evidence for durable cellulite or body-shaping changes is limited.
- Caffeine in Skincare: Its Role in Skin Cancer, Sun Protection, and Cosmetics ↗
Indian journal of dermatology · 2023 · DOI 10.4103/ijd.ijd_166_22
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This review outlines the current evidence for the use of caffeine in dermatologic anti-cancer topicals, sunscreens, and cosmetics.
Hyaluronic acid + occlusives
- What it's claimed to do
- Creates a moisture wrap for softer lips overnight.
- What the evidence says
- Humectants attract water and occlusive lipids slow evaporation. Berry extracts add antioxidant marketing but are not the main reason it works.
- In Laneige Lip Sleeping Mask →
- Hyaluronic acid: A key molecule in skin aging ↗
Dermato-endocrinology · 2012 · DOI 10.4161/derm.21923
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In the skin, hyaluronic acid is a key molecule involved in moisture due to its unique capacity to retain water.
- Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence ↗
Dermatologic therapy · 2022 · DOI 10.1111/dth.15903
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Across reviewed studies, topical hyaluronic acid improved skin hydration and some visible signs of aging.
Hydration + citric acid
- What it's claimed to do
- Detoxes the body, wakes up digestion, and boosts metabolism.
- What the evidence says
- Drinking water supports normal hydration, while lemon adds flavor and a little vitamin C. There is no clinical evidence that warm lemon water uniquely detoxes the body or meaningfully increases fat loss. Frequent acidic sipping can soften tooth enamel.
- In Daily ritual Morning Hot Lemon Water →
- Water, hydration, and health ↗
Nutrition reviews · 2010 · DOI 10.1111/j.1753-4887.2010.00304.x
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This review examines water intake's role in human health, the mechanisms of water homeostasis, and the health effects of varying water intake, noting a lack of long-term trials.
- Quantitative and spectroscopic assessment of early-stage enamel erosion induced by popular acidic beverages ↗
BMC oral health · 2025 · DOI 10.1186/s12903-025-07009-8
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In a laboratory study, a single 5-minute immersion in popular acidic beverages like soft drinks, energy drinks, and orange juice significantly increased the surface roughness of human tooth enamel.
Hypochlorous acid
- What it's claimed to do
- Calms redness and reduces acne-causing microbes.
- What the evidence says
- Hypochlorous acid is a genuine antimicrobial molecule used in wound care. Early dermatology use is promising, but this facial spray has less direct clinical evidence than established acne medicines.
- In Tower 28 SOS Daily Rescue Facial Spray →
- Hypochlorous Acid: A Review ↗
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020 · DOI 10.1016/j.joms.2020.06.029
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A review of the literature indicates that hypochlorous acid can be used with high predictability for disinfecting against the COVID-19 virus in clinical office settings.
- Hypochlorous Acid: Clinical Insights and Experience in Dermatology, Surgery, Dentistry, Ophthalmology, Rhinology, and Other Specialties ↗
Biomedicines · 2025 · DOI 10.3390/biomedicines13122921
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Reviews clinical uses of hypochlorous acid, including for inflamed and infection-prone skin.
Incline aerobic walking
- What it's claimed to do
- Burns fat and builds glutes better than ordinary walking.
- What the evidence says
- Brisk uphill walking raises heart rate and energy expenditure and supports established aerobic-health benefits. The exact 12-3-30 numbers have not been shown to be uniquely optimal and can be too demanding for beginners.
- In Treadmill routine 12-3-30 Incline Walking →
- The Physical Activity Guidelines for Americans ↗
JAMA · 2018 · DOI 10.1001/jama.2018.14854
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Regular moderate-to-vigorous aerobic activity consistently improves cardiovascular health and lowers chronic-disease risk.
- Association of Daily Step Count and Step Intensity With Mortality Among US Adults ↗
JAMA · 2020 · DOI 10.1001/jama.2020.1382
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In a study of US adults, taking more steps per day was associated with a lower risk of all-cause mortality; for example, taking 8,000 steps per day was linked to about half the mortality risk compared to taking 4,000 steps.
Irish sea moss
Also listed as Chondrus crispus
- What it's claimed to do
- Contains 92 minerals; boosts immunity, thyroid and energy.
- What the evidence says
- The '92 minerals' figure is folklore, not chemistry. Seaweed does carry iodine, and lab studies show prebiotic and antioxidant activity — but there are effectively no human trials for the claimed benefits.
- In Atlantic Bloom Wildcrafted Sea Moss Gel →
- Seaweeds as a Functional Ingredient for a Healthy Diet ↗
Marine drugs · 2020 · DOI 10.3390/md18060301
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A review of seaweeds describes them as a good source of nutrients like proteins, vitamins, and minerals, and notes they contain bioactive compounds with attributed antioxidant and anti-inflammatory properties.
- Commercially available kelp and seaweed products - valuable iodine source or risk of excess intake? ↗
Food & nutrition research · 2021 · DOI 10.29219/fnr.v65.7584
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An analysis of commercial seaweed products found that iodine content was highly variable, and a single serving of many products could exceed the tolerable upper intake level for iodine.
K18Peptide
Also listed as sh-Oligopeptide-78
- What it's claimed to do
- Reconnects keratin chains damaged by bleach and heat.
- What the evidence says
- The biomimetic theory is plausible and laboratory data are brand-backed, but independent peer-reviewed clinical comparisons of the proprietary sequence are limited.
- In K18 Leave-In Molecular Repair Hair Mask →
- Hair cosmetics: an overview ↗
International journal of trichology · 2015 · DOI 10.4103/0974-7753.153450
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This article reviews the formulations and mode of action of hair cosmetics like shampoos and conditioners to help dermatologists treat hair and scalp conditions.
- Health improvement of human hair and their reshaping using recombinant keratin K31 ↗
Biotechnology reports (Amsterdam, Netherlands) · 2018 · DOI 10.1016/j.btre.2018.e00288
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In a lab study, a recombinant human keratin protein (K31) increased the diameter and mechanical strength of chemically damaged hair.
L-theanine
- What it's claimed to do
- Relaxation without drowsiness.
- What the evidence says
- Short trials show reduced stress scores and better sleep quality at 200mg, but effects are modest and study lengths are weeks, not years.
- In Hush Labs Magnesium Glycinate Sleep Capsules →
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial ↗
Nutrients · 2019 · DOI 10.3390/nu11102362
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Four weeks of 200mg/day improved sleep-quality scores versus placebo.
- GABA and l-theanine mixture decreases sleep latency and improves NREM sleep ↗
Pharmaceutical biology · 2019 · DOI 10.1080/13880209.2018.1557698
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In an animal study, a mixture of GABA and L-theanine decreased sleep latency and increased sleep duration compared to either compound alone.
Magnesium glycinate
- What it's claimed to do
- Fixes insomnia and calms the nervous system.
- What the evidence says
- Meta-analyses find small improvements in sleep onset time, mostly in older adults who were low on magnesium to begin with. Quality of trials is low.
- In Hush Labs Magnesium Glycinate Sleep Capsules →
- The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial ↗
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012 · PMC3703169
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Improved sleep time and efficiency versus placebo in a small older-adult sample.
- Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis ↗
BMC complementary medicine and therapies · 2021 · DOI 10.1186/s12906-021-03297-z
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Evidence graded low quality; effect on falling asleep is real but small.
Manual lymphatic drainage
- What it's claimed to do
- Flushes toxins, removes bloating, and permanently sculpts the body.
- What the evidence says
- Manual lymphatic drainage has medical uses within lymphedema care. In healthy people, temporary fluid shifts can change appearance, but there is no evidence it removes fat or permanently reshapes the body.
- In Body-care treatment Lymphatic Drainage Massage →
- Manual lymphatic drainage for lymphedema following breast cancer treatment ↗
The Cochrane database of systematic reviews · 2015 · DOI 10.1002/14651858.CD003475.pub2
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This 2013 review aimed to assess the efficacy and safety of manual lymphatic drainage for treating breast cancer-related lymphedema.
- Effects of manual lymphatic drainage on total knee replacement: a systematic review and meta-analysis of randomized controlled trials ↗
BMC musculoskeletal disorders · 2024 · DOI 10.1186/s12891-023-07153-8
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Pools trials of lymphatic drainage for swelling after knee surgery, a medical setting rather than wellness massage.
Meadowfoam seed oil
- What it's claimed to do
- Adds antioxidant moisture support.
- What the evidence says
- It is primarily an emollient that improves feel and reduces dryness; sunscreen filters do the protective work.
- In Supergoop! Unseen Sunscreen SPF 40 →
- Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils ↗
International journal of molecular sciences · 2017 · DOI 10.3390/ijms19010070
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A review of various plant oils finds they can have therapeutic benefits for skin, including anti-inflammatory effects, promotion of wound healing, and repair of the skin barrier.
- Meadowfoam seed oil as a natural dispersing agent for colorants in lipstick ↗
International journal of cosmetic science · 2021 · DOI 10.1111/ics.12724
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Shows meadowfoam oil works well as a cosmetic base; it's a formulation study, not a skin-benefit trial.
Mechanical exfoliation
- What it's claimed to do
- Moves lymph, detoxes the body, and erases cellulite.
- What the evidence says
- A dry brush can lift loose surface cells and temporarily increase skin redness. Direct clinical evidence for lymphatic drainage, detoxification, or lasting cellulite reduction is absent.
- In Body-care ritual Dry Brushing Routine →
- Cellulite: Current Understanding and Treatment ↗
Aesthetic surgery journal. Open forum · 2023 · DOI 10.1093/asjof/ojad050
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Reviews what causes cellulite and which treatments have actually been tested in clinical studies.
- Insights Into the Pathophysiology of Cellulite: A Review ↗
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020 · DOI 10.1097/DSS.0000000000002388
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Explains cellulite as a structural feature of fat and connective tissue beneath the skin surface.
Multi-weight hyaluronic acid
- What it's claimed to do
- Hydrates multiple layers and visibly plumps skin.
- What the evidence says
- Hyaluronic acid is a proven humectant. Molecular size changes film behavior and penetration, but claims about reaching distinct deep layers are harder to establish.
- In The Ordinary Hyaluronic Acid 2% + B5 →
- Hyaluronic acid: A key molecule in skin aging ↗
Dermato-endocrinology · 2012 · DOI 10.4161/derm.21923
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In the skin, hyaluronic acid is a key molecule involved in moisture due to its unique capacity to retain water.
- Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence ↗
Dermatologic therapy · 2022 · DOI 10.1111/dth.15903
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Across reviewed studies, topical hyaluronic acid improved skin hydration and some visible signs of aging.
Nano-hydroxyapatite
Also listed as n-HAp
- What it's claimed to do
- Remineralises enamel as well as fluoride, without fluoride.
- What the evidence says
- Multiple randomised trials, many from Japan and Europe, find it non-inferior to fluoride for caries prevention in children and adults. Long-term population-level data is still thinner than fluoride's.
- In Enamel Theory Nano-Hydroxyapatite Toothpaste →
- Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial ↗
Frontiers in public health · 2023 · DOI 10.3389/fpubh.2023.1199728
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In an 18-month randomized trial in adults, a hydroxyapatite toothpaste was found to be non-inferior to a fluoride toothpaste in preventing an increase in decayed, missing, or filled tooth surfaces.
- Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis ↗
Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021 · PMC8641555
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A systematic review and meta-analysis of clinical trials found good evidence that fluoride-free hydroxyapatite oral care products effectively reduce dental caries.
Niacinamide
Also listed as Vitamin B3
- What it's claimed to do
- Calms redness and shrinks pores.
- What the evidence says
- Good data for barrier support, oil control and pigmentation at 2–5%. 'Pore shrinking' is not a thing pores actually do; the visual change is mostly reduced oil and swelling.
- In Northlight Lab Overnight Retinal 0.1% Serum →
- What it's claimed to do
- Brightens, supports the barrier, and minimizes pores.
- What the evidence says
- Niacinamide has clinical support for barrier lipids, uneven tone, and oil regulation. It can make pores look less visible but cannot change their anatomy.
- In Glow Recipe Watermelon Glow Niacinamide Dew Drops →
- Nicotinamide: Mechanism of action and indications in dermatology ↗
Indian journal of dermatology, venereology and leprology · 2018 · DOI 10.4103/ijdvl.IJDVL_286_17
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Supports barrier lipid synthesis and reduces inflammatory lesions; effects are modest but consistent.
- Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne ↗
The Cochrane database of systematic reviews · 2020 · DOI 10.1002/14651858.CD011368.pub2
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For acne, evidence on topical nicotinamide came from small trials and was rated low certainty.
Panthenol
Also listed as Pro-vitamin B5
- What it's claimed to do
- Supports barrier recovery.
- What the evidence says
- Panthenol is a useful humectant and soothing ingredient with supportive topical evidence.
- In The Ordinary Hyaluronic Acid 2% + B5 →
- Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils ↗
International journal of molecular sciences · 2017 · DOI 10.3390/ijms19010070
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A review of various plant oils finds they can have therapeutic benefits for skin, including anti-inflammatory effects, promotion of wound healing, and repair of the skin barrier.
- Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence ↗
Journal of clinical medicine · 2022 · DOI 10.3390/jcm11143943
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Topical dexpanthenol supports skin barrier repair and hydration, including in eczema-prone skin.
Passive heat exposure
- What it's claimed to do
- Detoxes the body and improves cardiovascular health.
- What the evidence says
- Heat exposure causes real cardiovascular responses and may modestly improve some vascular measures. Infrared-specific trials are small, and sweating does not meaningfully replace liver and kidney detoxification.
- In Wellness studio Infrared Sauna Sessions →
- Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review ↗
Evidence-based complementary and alternative medicine : eCAM · 2018 · DOI 10.1155/2018/1857413
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A systematic review found that while most of the 40 studies analyzed reported beneficial health effects from regular dry sauna bathing, the trials were generally small, heterogeneous, and more high-quality data is needed.
- A post-exercise infrared sauna session improves recovery of neuromuscular performance and muscle soreness after resistance exercise training ↗
Biology of sport · 2023 · DOI 10.5114/biolsport.2023.119289
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In a small trial, infrared sauna after strength training helped recovery of performance and soreness.
Peppermint oil
- What it's claimed to do
- Boosts follicle blood flow for faster growth.
- What the evidence says
- The famous result is a mouse study. The tingle you feel is a cold-receptor trick, not proof of circulation change in humans.
- In Wildroot Co. Rosemary Mint Scalp Growth Oil →
- Peppermint Oil Promotes Hair Growth without Toxic Signs ↗
Toxicological research · 2014 · DOI 10.5487/TR.2014.30.4.297
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Mice treated with 3% peppermint oil grew thicker hair than minoxidil controls. No human trial.
Pigment suspension + emollients
- What it's claimed to do
- Delivers weightless, lasting color with a soothing botanical blend.
- What the evidence says
- Film formers and pigment dispersion explain the long wear. Botanical extracts may support feel, but they are not proven treatment actives at cosmetic concentrations.
- In Rare Beauty Soft Pinch Liquid Blush →
- Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils ↗
International journal of molecular sciences · 2017 · DOI 10.3390/ijms19010070
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A review of various plant oils finds they can have therapeutic benefits for skin, including anti-inflammatory effects, promotion of wound healing, and repair of the skin barrier.
Progressive resistance + motor control
- What it's claimed to do
- Builds core strength, improves function, and creates long lean muscles.
- What the evidence says
- Pilates can improve strength, balance, flexibility, and pain-related function, especially in beginners and people with low-back pain. It does not uniquely lengthen muscles or change genetically determined body shape.
- In Club Pilates + independent studios Reformer Pilates →
- Benefits of Pilates in the Elderly Population: A Systematic Review and Meta-Analysis ↗
European journal of investigation in health, psychology and education · 2022 · DOI 10.3390/ejihpe12030018
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A systematic review and meta-analysis of 30 studies found that Pilates improved dynamic balance, strength, mobility, and other health measures in adults over 60.
- Pilates for low back pain ↗
The Cochrane database of systematic reviews · 2015 · DOI 10.1002/14651858.CD010265.pub2
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Based on low-quality evidence from a Cochrane review, Pilates may reduce pain in the short term for people with low back pain when compared to minimal intervention.
Retinaldehyde
Also listed as Retinal, vitamin A aldehyde
- What it's claimed to do
- Smooths fine lines and clears breakouts faster than retinol.
- What the evidence says
- Retinoids are among the most heavily studied topical actives. Retinaldehyde converts to retinoic acid in one step instead of two, so it acts faster than retinol at similar tolerability.
- In Northlight Lab Overnight Retinal 0.1% Serum →
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety ↗
Clinical interventions in aging · 2006 · DOI 10.2147/ciia.2006.1.4.327
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This overview notes that while many retinoids have shown histological and clinical improvement for skin aging, particularly photoaging, their use is often limited by skin irritation.
- Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations ↗
Advances in therapy · 2022 · DOI 10.1007/s12325-022-02319-7
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This review found a lack of evidence from properly designed clinical trials to support the claimed anti-aging efficacy of commonly used retinoids in cosmeceuticals.
Rosemary oil
Also listed as Rosmarinus officinalis leaf oil
- What it's claimed to do
- Regrows hair as well as minoxidil.
- What the evidence says
- One 2015 trial in men with pattern hair loss found rosemary oil matched 2% minoxidil at six months. It is a single, modest-quality study — promising, not settled.
- In Wildroot Co. Rosemary Mint Scalp Growth Oil →
- Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial ↗
Skinmed · 2015 · PMID 25842469
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Both groups gained hair count at 6 months; rosemary caused less scalp itching.
- Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets ↗
Molecules (Basel, Switzerland) · 2024 · DOI 10.3390/molecules29102288
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A review of plant extracts found that several have shown hair growth-promoting efficacy in clinical trials by modulating cellular pathways and growth factors.
Shea butter + vegan waxes
- What it's claimed to do
- Softens dry lips and seals in moisture.
- What the evidence says
- Emollient lipids smooth rough surface cells while waxes reduce water loss. The effect is protective, not permanent repair.
- In Summer Fridays Lip Butter Balm →
- Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils ↗
International journal of molecular sciences · 2017 · DOI 10.3390/ijms19010070
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A review of various plant oils finds they can have therapeutic benefits for skin, including anti-inflammatory effects, promotion of wound healing, and repair of the skin barrier.
Signal peptides
- What it's claimed to do
- Supports firmer-looking skin.
- What the evidence says
- Some peptide sequences have topical evidence, but results cannot be generalized to every proprietary blend.
- In Drunk Elephant D-Bronzi Anti-Pollution Sunshine Drops →
- Oral and topical peptides for skin aging: systematic review and meta-analysis of randomized controlled trials ↗
Frontiers in medicine · 2026 · DOI 10.3389/fmed.2026.1618306
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This meta-analysis of 19 randomized controlled trials found that peptides, particularly oral formulations, significantly improved skin hydration and brightness, with a modest effect on wrinkle reduction.
- Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy ↗
International journal of molecular sciences · 2025 · DOI 10.3390/ijms26125722
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Reviews a widely used cosmetic peptide: skin penetration is limited and wrinkle results vary between studies.
Snail secretion filtrate
- What it's claimed to do
- Repairs the barrier, fades scars, heals everything.
- What the evidence says
- Contains glycosaminoglycans, glycoproteins and zinc. Small human studies show improved hydration and some wound-healing support; scar-fading claims outrun the data.
- In Seolhwa 96% Snail Mucin Repair Essence →
- Hidden benefits of snail mucus: A natural skincare marvel ↗
Biomolecules & biomedicine · 2024 · DOI 10.17305/bb.2024.11067
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A review of snail mucus highlights its scientifically proven performance in dermatology for effects like tissue repair, hydration, and anti-aging, while noting that much remains unexplored.
- HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts ↗
Scientific reports · 2018 · DOI 10.1038/s41598-018-35816-3
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Demonstrates fibroblast stimulation in lab models supporting repair claims.
Sodium hyaluronate
- What it's claimed to do
- Deep hydration.
- What the evidence says
- Well-established humectant: reliably increases skin water content and smooths surface texture short-term.
- In Seolhwa 96% Snail Mucin Repair Essence →
- Hyaluronic acid: A key molecule in skin aging ↗
Dermato-endocrinology · 2012 · DOI 10.4161/derm.21923
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This review describes hyaluronic acid as a key molecule for skin moisture, responsible for the skin's turgor, resilience, and pliability.
- Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence ↗
Dermatologic therapy · 2022 · DOI 10.1111/dth.15903
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Across reviewed studies, topical hyaluronic acid improved skin hydration and some visible signs of aging.
Sodium, potassium + fluid
- What it's claimed to do
- Everyone who fasts needs electrolyte supplements for energy and safety.
- What the evidence says
- Electrolytes are essential, but most healthy people doing short fasts do not automatically need supplements. Needs rise with prolonged fasting, heavy sweating, illness, or certain medications; excess intake can also be harmful.
- In Nutrition routine Electrolyte Fasting →
- Water, hydration, and health ↗
Nutrition reviews · 2010 · DOI 10.1111/j.1753-4887.2010.00304.x
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This review examines current knowledge on water intake and health, highlighting the complexity of water homeostasis and major gaps in research.
- Rehydration during Endurance Exercise: Challenges, Research, Options, Methods ↗
Nutrients · 2021 · DOI 10.3390/nu13030887
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Sodium and fluid needs depend heavily on sweat losses and activity level.
Time under tension
- What it's claimed to do
- Slow continuous resistance builds muscle and cardio fitness in one class.
- What the evidence says
- The underlying principles—resistance, proximity to fatigue, and progressive overload—can stimulate strength and hypertrophy. Lagree itself has little independent clinical research, so claims of unique superiority are unproven.
- In Lagree + Megaformer studios Lagree Fitness →
- Resistance training prescription for muscle strength and hypertrophy in healthy adults: a systematic review and Bayesian network meta-analysis ↗
British journal of sports medicine · 2023 · DOI 10.1136/bjsports-2023-106807
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A network meta-analysis found that while heavier loads were best for maximizing strength, different resistance training protocols (varying in load, sets, and frequency) produced comparable gains in muscle hypertrophy.
- Effects of resistance training performed to repetition failure or non-failure on muscular strength and hypertrophy: A systematic review and meta-analysis ↗
Journal of sport and health science · 2022 · DOI 10.1016/j.jshs.2021.01.007
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Training effort matters, but reaching total failure every set is not required for strength or hypertrophy.
Xylitol
- What it's claimed to do
- Starves cavity bacteria.
- What the evidence says
- Reduces Streptococcus mutans counts; Cochrane reviews find the cavity-prevention benefit real but smaller than marketing implies.
- In Enamel Theory Nano-Hydroxyapatite Toothpaste →
- Xylitol-containing products for preventing dental caries in children and adults ↗
The Cochrane database of systematic reviews · 2015 · DOI 10.1002/14651858.CD010743.pub2
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Low-quality evidence of modest caries reduction, mainly from fluoride-xylitol toothpaste.